G2E3 attenuating replicative stress
نویسندگان
چکیده
منابع مشابه
G2E3 attenuating replicative stress
cells generally display an increased level of replicative stress. While in S phase, their replication forks undergo temporary stalling and sometimes even permanent collapse, leading to the accumulation of single stranded DNA and a DNA damage response. Strategies to exploit this phenomenon by further increasing replicative stress include the use of conventional DNA-damaging chemotherapeutics, bu...
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ژورنال
عنوان ژورنال: Aging
سال: 2015
ISSN: 1945-4589
DOI: 10.18632/aging.100784